Elghryani Nagwa, Lawlor Amanda, McOwan Trish, de Waal Theo
School of Veterinary Medicine, University College Dublin, D04 W6F6 Dublin, Ireland.
Telenostic Limited, R95 WN20 Kilkenny, Ireland.
Animals (Basel). 2024 Jul 2;14(13):1958. doi: 10.3390/ani14131958.
Over the preceding decades, the widespread dependence on anthelmintic drugs for managing nematodes in grazing equids has given rise to resistance against commonly used anthelmintics in various countries. This study explores the prevalence of anthelmintic resistance across 44 horse farms in Ireland. Anthelmintic efficacy was evaluated through fecal egg count reduction (FECR) tests employing the mini-FLOTAC technique. Resistance to benzimidazoles was identified in 12 out of 14 farms (FECR range: 0.00% to 86.2%). Ivermectin resistance was observed on two farms, one with an FECR of 80.70% and another with an FECR of 96.10% (lower 95% high probability density interval (HPD) <90%, 11.70%). On the remaining six farms, the reduction with ivermectin still exceeded 95%. The reduced efficacy of moxidectin was noted on two farms (FECR = 86.90% and 93.50%) and on a third farm with an FECR of 99.50 and a lower HPD interval < 90% at 24.00%. In summary, these findings emphasize the urgent need for alternative strategies in equine strongyle control that reduce reliance on anthelmintics and prioritize effective management practices on Irish equine farms to hinder the impending development of drug-resistant parasite populations.
在过去几十年里，放牧马属动物中广泛依赖驱虫药物来控制线虫，导致各国对常用驱虫药物产生了抗药性。本研究探讨了爱尔兰44个马场驱虫抗药性的流行情况。采用小型漂浮技术通过粪便虫卵计数减少（FECR）试验评估驱虫效果。在14个马场中的12个马场发现了对苯并咪唑类药物的抗药性（FECR范围：0.00%至86.2%）。在两个马场观察到伊维菌素抗药性，一个马场的FECR为80.70%，另一个马场的FECR为96.10%（较低的95%高概率密度区间（HPD）<90%，11.70%）。在其余六个马场，伊维菌素的减少率仍超过95%。在两个马场（FECR = 86.90%和93.50%）以及第三个马场（FECR为99.50%，24.00%时较低的HPD区间<90%）注意到莫西菌素的疗效降低。总之，这些发现强调迫切需要采取替代策略来控制马属动物的圆线虫，减少对驱虫药物的依赖，并优先在爱尔兰马场采取有效的管理措施，以阻止耐药寄生虫种群的即将出现。
