Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of West 5th Road, Xi'an, ShanXi, 710049, People's Republic of China.
BMC Endocr Disord. 2019 Nov 26;19(1):127. doi: 10.1186/s12902-019-0452-6.
We measured the concentrations of the adipocytokines vaspin and visfatin in obese Chinese children. Furthermore, we studied the correlation of these adipocytokines with early-onset metabolic and vascular sequelae among these children.
A total of 244 children (160 obese and 84 lean) were included in this study. Vaspin and visfatin were detected using enzyme-linked immunosorbent assays. We also assayed other metabolic and cardiovascular parameters. The associations of serum vaspin and visfatin concentrations with metabolic and cardiovascular parameters were determined.
We found a significant elevation in the concentrations of vaspin and visfatin in obese children compared to the concentrations in lean children. Additionally, we found a significant positive correlation between visfatin and vaspin levels, as well as inflammatory cell infiltration and markers of endothelial activation, but these factors did not affect insulin resistance in obese children. Multiple regression analyses confirmed that vaspin is the strongest predictor of higher tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiotensin-2 (Ang-2), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin levels. We also found a significant association between visfatin and Ang-2, IL-6, VCAM-1, and E-selectin levels.
The adipocytokines vaspin and visfatin are significantly interrelated, and both adipocytokines play a role in vascular endothelial function and inflammation.
我们测定了肥胖中国儿童体内脂肪细胞因子内脂素和内脏脂肪素的浓度。此外，我们还研究了这些脂肪细胞因子与儿童早期发生的代谢和血管并发症的相关性。
本研究共纳入 244 名儿童（160 名肥胖儿童和 84 名正常体重儿童）。采用酶联免疫吸附试验检测内脂素和内脏脂肪素的浓度。同时检测其他代谢和心血管参数。分析血清内脂素和内脏脂肪素浓度与代谢和心血管参数的相关性。
与正常体重儿童相比，肥胖儿童的内脂素和内脏脂肪素浓度显著升高。此外，我们发现内脏脂肪素和内脂素水平与炎症细胞浸润和血管内皮细胞激活标志物呈显著正相关，但这些因素并不影响肥胖儿童的胰岛素抵抗。多元回归分析证实，内脂素是肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血管紧张素-2（Ang-2）、血管细胞黏附分子-1（VCAM-1）和 E-选择素水平升高的最强预测因子。我们还发现内脏脂肪素与 Ang-2、IL-6、VCAM-1 和 E-选择素水平之间存在显著相关性。
脂肪细胞因子内脂素和内脏脂肪素之间存在显著的相互关系，这两种脂肪细胞因子均参与血管内皮功能和炎症反应。
