Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, W B, India.
Biotechnol Adv. 2013 Mar-Apr;31(2):338-45. doi: 10.1016/j.biotechadv.2013.01.004. Epub 2013 Jan 12.
Lipopeptides are compounds that are formed by cyclic or short linear peptides linked with a lipid tail or other lipophilic molecules. Recently, several lipopeptides were characterized, showing surfactant, antimicrobial and cytotoxic activities. The properties of lipopeptides may lead to applications in diverse industrial fields including the pharmaceutical industry as conventional antibiotics; the cosmetic industry for dermatological product development due to surfactant and anti-wrinkle properties; in food production acting as emulsifiers in various foodstuffs; and also in the field of biotechnology as biosurfactants. Some lipopeptides have reached a commercial antibiotic status, such as daptomycin, caspofungin, micafungin, and anidulafungin. This will be the focus of this review. Moreover, the review presented here will focus on the biotechnological utilization of lipopeptides in different fields as well as the functional-structure relation, connecting recent aspects of synthesis and structure diversity.
脂肽是由环状或短线性肽与脂质尾部或其他亲脂性分子连接形成的化合物。最近，已经有几种脂肽被鉴定出来，具有表面活性剂、抗菌和细胞毒性活性。脂肽的性质可能导致其在不同的工业领域得到应用，包括制药工业作为传统抗生素；化妆品工业用于开发具有表面活性剂和抗皱性能的皮肤病学产品；在食品生产中作为各种食品的乳化剂；以及生物技术领域作为生物表面活性剂。一些脂肽已经达到了商业抗生素的地位，如达托霉素、卡泊芬净、米卡芬净和阿尼达弗。这将是本综述的重点。此外，本文综述将重点介绍脂肽在不同领域的生物技术利用以及功能-结构关系，连接最近的合成和结构多样性方面。
