Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Int J Gynecol Cancer. 2013 Feb;23(2):325-30. doi: 10.1097/IGC.0b013e318280810a.
Cluster of differentiation (CD) 24 is a cell adhesion molecule that has been implicated in tumor invasion and metastasis of various solid tumors. The aim of this study was to explore the expression patterns of CD24 as a predictive marker for long-term survival in cervical carcinomas.
A total of 144 patients diagnosed with International Federation of Gynecology and Obstetrics stage I to IV cervical carcinoma were studied, and 95 patients underwent surgical intervention. The expression of CD24 protein was studied by immunohistochemistry using tissue microarrays.
Overexpression of CD24 was observed in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24 overexpression had poorer survival compared with that of patients with CD24 underexpression (5-year survival rate, 52.0% vs 72.3%; log rank P = 0.014). Importantly, in multivariate analysis, CD24 overexpression proved to be a significant independent predictor of short-term survival (relative risk, 1.814; P = 0.043).
The present study suggests that CD24 overexpression is a predictor of decreased long-term survival in patients with cervical carcinoma. Therefore, immunohistochemical evaluation of CD24 expression is a potential prognostic biomarker for cervical carcinomas.
分化簇 24（CD24）是一种细胞黏附分子，与多种实体瘤的侵袭和转移有关。本研究旨在探讨 CD24 的表达模式是否可作为预测宫颈癌患者长期生存的标志物。
本研究共纳入 144 例国际妇产科联盟（FIGO）Ⅰ期至Ⅳ期宫颈癌患者，其中 95 例行手术干预。采用组织微阵列免疫组织化学法检测 CD24 蛋白的表达。
在 144 例浸润性癌中，有 50 例（34.7%）存在 CD24 过表达。与 CD24 低表达者相比，CD24 过表达者的生存状况较差（5 年生存率分别为 52.0%和 72.3%；log rank P = 0.014）。重要的是，多因素分析显示，CD24 过表达是短期生存的独立显著预测因子（相对风险，1.814；P = 0.043）。
本研究表明，CD24 过表达是宫颈癌患者长期生存降低的预测因子。因此，CD24 表达的免疫组化评估可能是宫颈癌的一种潜在预后生物标志物。
