Dermatology Department, Hôtel-Dieu de France Hospital, Beirut, Lebanon.
Lasers Med Sci. 2013 Jul;28(4):1205-7. doi: 10.1007/s10103-012-1263-4. Epub 2013 Jan 15.
Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. We describe a case of Fox-Fordyce disease that developed in a 27-year-old woman 3 months after she had completed two LightSheer Diode laser treatments of her axilla, periumbilical region, and bikini area. Clinical and histopathological changes are as well detailed. Laser therapy induces damage to follicular infundibulum, resulting in altered maturation of keratinocytes which led to keratin plugging causing the common pathologic features in Fox-Fordyce disease. Differences in the physiologic features of the anatomic sites, in the susceptibility to laser-induced injury among these areas, or additional factors may contribute to Fox-Fordyce disease.
狐 - Fordyce 病是一种罕见的顶泌汗腺炎症性疾病。最近有两项报告表明，激光脱毛是腋部 Fox-Fordyce 病的新发病因。我们报告首例女性 Fox-Fordyce 病在腋部、脐部和耻骨部完成脱毛激光治疗后发生。我们描述了一位 27 岁女性的病例，她在完成两次 LightSheer 二极管激光腋部、脐周和比基尼区治疗后 3 个月出现 Fox-Fordyce 病。详细描述了临床和组织病理学变化。激光治疗导致毛囊漏斗损伤，导致角朊细胞成熟异常，从而导致角蛋白栓形成，导致 Fox-Fordyce 病的常见病理特征。这些部位的解剖部位的生理特征、对激光诱导损伤的易感性或其他因素的差异可能导致 Fox-Fordyce 病。
