Medical University of South Carolina, Charleston, SC 29425, USA.
J Clin Rheumatol. 2013 Jan;19(1):38-42. doi: 10.1097/RHU.0b013e31827cd112.
Oncogenic osteomalacia is a rare paraneoplastic syndrome of systemic bone demineralization secondary to a tumor-induced dysregulation of phosphorus metabolism. The tumor's low prevalence, small size, and variable location often result in years of muscular weakness and bone pain before diagnosis. With complete treatment, patient's symptoms swiftly dissipate. We report the case of a 63-year-old previously healthy man with a 20-month course of musculoskeletal symptoms before diagnosis and resection of a posterior tibial tumor. Postoperatively, the patient had returned to his previous lifestyle when an insufficiency fracture required prophylactic stabilization.
成骨性骨软化症是一种罕见的副瘤综合征，表现为全身性骨矿化不良，继发于肿瘤引起的磷代谢紊乱。由于肿瘤的低发病率、小尺寸和可变位置，通常在诊断前会出现数年的肌肉无力和骨痛。通过完整的治疗，患者的症状会迅速消失。我们报告了一例 63 岁的健康男性，在诊断和切除胫骨后肿瘤之前，经历了 20 个月的肌肉骨骼症状。术后，当需要预防性稳定时，患者发生了一处骨折，随后回到了之前的生活方式。
