Burleigh D E
Department of Pharmacology, London Hospital Medical College, London, U.K.
Dig Dis Sci. 1990 May;35(5):617-21. doi: 10.1007/BF01540410.
There is an increasing body of evidence suggesting regional heterogeneity in human colonic function. Using circular and longitudinal muscle strips from proximal and distal human colon, the present study sought to determine whether such regional differences were apparent in smooth muscle responsiveness to neurohumoral agents. Both proximal and distal muscle gave quantitatively similar responses to acetylcholine, as they did for noradrenaline. However, the circular muscle of the distal colon was more sensitive to vasoactive intestinal peptide than was the circular muscle of the proximal colon. Longitudinal muscle from both regions was comparatively insensitive to VIP.
越来越多的证据表明人类结肠功能存在区域异质性。本研究使用来自人类结肠近端和远端的环形和纵行肌条，试图确定这种区域差异在平滑肌对神经体液因子的反应中是否明显。近端和远端肌肉对乙酰胆碱的反应在数量上相似，对去甲肾上腺素的反应也是如此。然而，远端结肠的环形肌对血管活性肠肽比近端结肠的环形肌更敏感。两个区域的纵行肌对血管活性肠肽相对不敏感。
