Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, England, UK.
J Exp Med. 2013 Jan 14;210(1):1-3. doi: 10.1084/jem.20122739.
Relatively few cancers arise in mature, differentiated cells. The propensity of mature B cells to transform has been linked to their longevity and proliferative potential, and stimulation of the B cell receptor (BCR) by cognate antigen may promote the transformation process. A study in this issue (Hoogeboom et al.) lends support to this notion, showing that cancer cells from a subset of patients with chronic lymphocytic leukemia (CLL) express a BCR specific for a sugar expressed by commensal yeast species. Another study, in contrast, suggests that B-CLL cells uniquely acquire the ability to signal in the complete absence of ligand.
相对较少的癌症发生在成熟分化的细胞中。成熟 B 细胞发生转化的倾向与其寿命和增殖潜能有关，并且同源抗原刺激 B 细胞受体 (BCR) 可能促进转化过程。本期中的一项研究（Hoogeboom 等人）支持这一观点，表明慢性淋巴细胞白血病 (CLL) 患者亚群的癌细胞表达一种 BCR，该 BCR 特异性识别共生酵母物种表达的糖。另一项研究则表明，B-CLL 细胞在完全没有配体的情况下独特地获得了信号转导的能力。
