Boehm G, Müller D M, Teichmann B, Krumbiegel P
Department of Paediatrics, Karl-Marx-University, Leipzig, German Democratic Republic.
Eur J Pediatr. 1990 Mar;149(6):396-8. doi: 10.1007/BF02009657.
To establish nutritional management of low birth-weight infants according to their individual metabolic situation, hepatocellular partial function was studied in 13 appropriate (AGA) and 11 small-for-gestational-age (SGA) low birthweight (LBW) infants during the first weeks of postnatal life. The concentrations of total bile acids and of alpha-amino-nitrogen in serum, the renal excretion of urea and ammonia and the renal excretion of 15N after enteral administration of 3 mg 15N-labeled methacetin/kg were measured. In comparison to AGA infants, SGA infants had elevated serum concentrations of total bile acids and of alpha-amino-nitrogen, decreased excretion of urea, increased excretion of ammonia in urine, and lower urinary 15N-excretion after enteral administration of 15N-labeled methacetin. The data suggest that hepatocellular functions are influenced by intrauterine growth retardation resulting in a reduced metabolic capacity in SGA infants. The metabolic differences between SGA and AGA infants should be considered in the nutritional management of LBW infants.
为根据低体重儿的个体代谢状况制定营养管理方案，在出生后的头几周对13例适于胎龄（AGA）和11例小于胎龄（SGA）的低体重（LBW）婴儿的肝细胞部分功能进行了研究。测定了血清中总胆汁酸和α-氨基氮的浓度、尿素和氨的肾排泄量以及经肠道给予3mg 15N标记的甲醋氨酚/kg后15N的肾排泄量。与AGA婴儿相比，SGA婴儿血清总胆汁酸和α-氨基氮浓度升高，尿素排泄减少，尿氨排泄增加，经肠道给予15N标记的甲醋氨酚后尿15N排泄降低。数据表明，肝细胞功能受宫内生长迟缓影响，导致SGA婴儿代谢能力降低。在LBW婴儿的营养管理中应考虑SGA和AGA婴儿之间的代谢差异。
