日本类风湿关节炎和系统性红斑狼疮患者中 HLA-DPB1*05:01 频率增加与抗 Ro/SS-A 和抗 La/SS-B 抗体的存在相关。
Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients.
机构信息
Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan.
出版信息
PLoS One. 2013;8(1):e53910. doi: 10.1371/journal.pone.0053910. Epub 2013 Jan 8.
INTRODUCTION
Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few have been validated in RA subpopulations with anti-La/SS-B or anti-Ro/SS-A antibodies. Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA.
METHODS
An association study was conducted for HLA-DRB1, DQB1, and DPB1 in Japanese RA and systemic lupus erythematosus (SLE) patients that were positive or negative for anti-Ro/SS-A and/or anti-La/SS-B antibodies.
RESULTS
An increased prevalence of certain class II alleles was associated with the presence of anti-Ro/SS-A antibodies as follows: DRB108:03 (Pc = 3.79×10(-5), odds ratio [OR] 3.06, 95% confidence interval [CI] 1.98-4.73), DQB106:01 (Pc = 0.0106, OR 1.70, 95%CI 1.26-2.31), and DPB105:01 (Pc = 0.0040, OR 1.55, 95%CI 1.23-1.96). On the other hand, DRB115:01 (Pc = 0.0470, OR 3.14, 95%CI 1.63-6.05), DQB106:02 (Pc = 0.0252, OR 3.14, 95%CI 1.63-6.05), and DPB105:01 (Pc = 0.0069, OR 2.27, 95% CI 1.44-3.57) were associated with anti-La/SS-B antibodies. The DPB1*05:01 allele was associated with anti-Ro/SS-A (Pc = 0.0408, OR 1.69, 95% CI 1.19-2.41) and anti-La/SS-B antibodies (Pc = 2.48×10(-5), OR 3.31, 95%CI 2.02-5.43) in SLE patients.
CONCLUSION
HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.
介绍
核糖核蛋白自身抗体与多种自身免疫性疾病相关，包括类风湿关节炎（RA）。已有许多关于人类白细胞抗原（HLA）等位基因与 RA 之间关联的研究，但在具有抗 La/SS-B 或抗 Ro/SS-A 抗体的 RA 亚群中进行验证的研究较少。在此，我们研究了 HLA Ⅱ类等位基因与 RA 患者抗 Ro/SS-A 或抗 La/SS-B 抗体存在之间的关联。
方法
对日本 RA 和系统性红斑狼疮（SLE）患者的 HLA-DRB1、DQB1 和 DPB1 进行关联研究，这些患者的抗 Ro/SS-A 和/或抗 La/SS-B 抗体呈阳性或阴性。
结果
某些 II 类等位基因的患病率增加与抗 Ro/SS-A 抗体的存在有关，具体如下：DRB108:03（Pc=3.79×10(-5)，比值比[OR]3.06，95%置信区间[CI]1.98-4.73），DQB106:01（Pc=0.0106，OR 1.70，95%CI 1.26-2.31）和 DPB105:01（Pc=0.0040，OR 1.55，95%CI 1.23-1.96）。另一方面，DRB115:01（Pc=0.0470，OR 3.14，95%CI 1.63-6.05），DQB106:02（Pc=0.0252，OR 3.14，95%CI 1.63-6.05）和 DPB105:01（Pc=0.0069，OR 2.27，95%CI 1.44-3.57）与抗 La/SS-B 抗体有关。DPA1*05:01 等位基因与抗 Ro/SS-A（Pc=0.0408，OR 1.69，95%CI 1.19-2.41）和抗 La/SS-B 抗体（Pc=2.48×10(-5)，OR 3.31，95%CI 2.02-5.43）在 SLE 患者中相关。
结论
在日本 RA 和 SLE 患者中，HLA-DPB1*05:01 是唯一与抗 Ro/SS-A 和抗 La/SS-B 抗体同时存在相关的等位基因。
Zotero 插件