Faculty of Chemical Engineering and Light Industry, Guang Dong University of Technology, Guang Dong, 510006, China.
Chem Commun (Camb). 2013 May 14;49(39):4127-44. doi: 10.1039/c2cc36698c. Epub 2013 Jan 15.
The use of multiple-center intramolecular H-bonds for the efficient construction of macrocycles of varying structures and functions is among the newest and the most noteworthy additions to the toolbox for macrocycle synthesis. This strategy has allowed the creation of sizable interior cavities as small as 2.8 Å and as large as 15 Å in radius in these H-bonded macrocycles with a number of them expressing tailor-made functions. While concentrating on our recent contributions to this fast-growing field, we will further summarize the latest advances on the design, synthesis, structure and function of these shape-persistent H-bonded macrocyclic foldamers that have helped to create a whole new dimension of scientific research, markedly expanding both the structural and functional repertoires of shape-persistent macrocycles.
使用多中心分子内氢键来高效构建具有不同结构和功能的大环是大环合成工具盒中最新和最值得注意的补充之一。这种策略允许在这些氢键大环中创建大小从 2.8 Å 到 15 Å 的相当大的内部空腔，其中许多大环具有定制功能。在关注我们在这个快速发展的领域的最新贡献的同时，我们将进一步总结这些具有持久形状的氢键大环折叠物的设计、合成、结构和功能的最新进展，这有助于创造一个全新的科学研究维度，显著扩展了具有持久形状的大环的结构和功能范围。
