College of Chemistry, Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China.
Molecules. 2023 May 30;28(11):4437. doi: 10.3390/molecules28114437.
Research on stimuli-responsive host-guest systems is at the cutting edge of supramolecular chemistry, owing to their numerous potential applications such as catalysis, molecular machines, and drug delivery. Herein, we present a multi-responsive host-guest system comprising azo-macrocycle 1 and 4,4'-bipyridinium salt for pH-, photo-, and cation- responsiveness. Previously, we reported a novel hydrogen-bonded azo-macrocycle 1. The size of this host can be controlled through light-induced E↔Z photo-isomerization of the constituent azo-benzenes. The host is found in this work to be capable of forming stable complexes with bipyridinium/pyridinium salts, and implementing guest capture and release with under light in a controlled manner. The binding and release of the guest in the complexes can also be easily controlled reversibly by using acid and base. Moreover, the cation competition-induced dissociation of the complex ⊃ is achieved. These findings are expected to be useful in regulating encapsulation for sophisticated supramolecular systems.
刺激响应主体-客体体系的研究处于超分子化学的前沿，因为它们具有许多潜在的应用，如催化、分子机器和药物传递。在此，我们提出了一个由偶氮大环 1 和 4,4'-联吡啶盐组成的多响应主体-客体体系，用于 pH、光和阳离子响应。此前，我们报道了一种新型的氢键偶氮大环 1。通过组成的偶氮苯的光诱导 E↔Z 光异构化，可以控制这种主体的大小。本工作发现，该主体能够与联吡啶/吡啶盐形成稳定的配合物，并在光下以可控的方式实现客体的捕获和释放。配合物中客体的结合和释放也可以通过酸和碱轻松地进行可逆控制。此外，还实现了配合物 ⊃ 中阳离子竞争诱导的解离。这些发现有望用于调节复杂超分子体系的封装。
