[α-鹅膏蕈碱给药对大鼠肝细胞核中锰离子依赖性多聚腺苷酸聚合酶的影响]
[Effect of administration of alpha-amanitine on Mn2+ - dependent poly-A-polymerase in rat liver nuclei].
作者信息
Corti A, Moruzzi M S, Capone G, Casti A
出版信息
Ateneo Parmense Acta Biomed. 1979;50(1):93-5.
PMID:233204
Abstract
Mn2+-dependent poly(A) polymerase activity tested in isolated rat liver nuclei is unchanged both in the absence and presence of exogenous poly(A) 30 min. after administration of a dose of alpha-amanitin that inhibits DNA-dependent RNA polymerase B. Longer times of treatment cause poly(A) polymerase to drop to 50% in the absence of poly(A) and to increase almost twice in its presence.
摘要
在分离的大鼠肝细胞核中检测到的锰离子依赖性聚腺苷酸聚合酶活性，在给予抑制DNA依赖性RNA聚合酶B的剂量的α-鹅膏蕈碱30分钟后，无论有无外源性聚腺苷酸，其活性均未改变。更长时间的处理会导致在没有聚腺苷酸的情况下聚腺苷酸聚合酶降至50%，而在有聚腺苷酸的情况下其活性几乎增加两倍。
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