骨形态发生蛋白/成纤维细胞生长因子2拮抗剂作为肺部转移休眠的决定性因素。
BMP/Coco antagonism as a deterministic factor of metastasis dormancy in lung.
作者信息
Martinez Jarrod, Zhang Xiang H-F
出版信息
Breast Cancer Res. 2013 Jan 15;15(1):302. doi: 10.1186/bcr3350.
Abstract
A recent Cell publication demonstrates that the secreted antagonist of transforming growth factor-beta ligands, Coco, can re-activate previously dormant metastatic breast cancer cells specifically in the lung by inhibiting bone morphogenetic protein (BMP) signaling. The authors provided evidence for a connection between Coco/BMP signaling and molecular and cellular traits of cancer stem cells. Their findings represent a significant advance in our understanding of metastatic dormancy, an extremely important clinical issue that remains understudied. Equally as important, this study also opens interesting avenues for future research.
摘要
《细胞》杂志最近发表的一篇文章表明，转化生长因子-β配体的分泌型拮抗剂可可（Coco），能够通过抑制骨形态发生蛋白（BMP）信号传导，特异性地重新激活此前处于休眠状态的转移性乳腺癌细胞，且这种激活作用尤其发生在肺部。作者提供了证据，证明可可/BMP信号传导与癌症干细胞的分子及细胞特征之间存在联系。他们的研究结果代表了我们在转移性休眠这一理解上的重大进展，转移性休眠是一个极为重要但仍未得到充分研究的临床问题。同样重要的是，这项研究也为未来的研究开辟了有趣的途径。
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本文引用的文献
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