Geriatric Research Center, Landspitali University Hospital, Reykjavik, Iceland.
J Am Geriatr Soc. 2013 Feb;61(2):237-42. doi: 10.1111/jgs.12077. Epub 2013 Jan 15.
To examine the long-term association between midlife physical activity (PA) and lower extremity function (LEF) in late life.
Longitudinal study with an average of 25 years of follow-up.
Community-dwelling old population in Reykjavik, Iceland.
Four thousand seven hundred fifty-three community-dwelling men and women (mean age 76 ± 6) in Reykjavik, Iceland.
On the basis of weekly hours of regular PA reported at the midlife examination, participants were classified as active or inactive. Measures of LEF in late life were gait speed on a 6-m walk, Timed Up and Go (TUG), and knee extension (KE) strength tests. Linear regression analysis was used to examine the association.
Participants who were active in midlife had significantly better LEF (faster gait speed, β = 0.50, P ≤ .001; faster TUG time, β = -0.53 P ≤ .001; stronger KE strength, β = 1.3, P ≤ .001) in late life than those who were not active in midlife after adjusting for sociodemographic and cardiovascular risk factors. After adjustment for cognitive function in late life (speed of processing, memory, and executive function), participants who were active in midlife had significantly faster gait speed (β = 0.04, P ≤ .001), faster TUG time (β = -0.34, P ≤ .001), and greater KE strength (β = 0.87, P ≤ .001) in old age than those who were not active in midlife.
Regular PA in midlife is associated with better performance of LEF in later life, even after controlling for late-life cognitive function.
探讨中年体力活动（PA）与晚年下肢功能（LEF）之间的长期关联。
平均随访 25 年的纵向研究。
冰岛雷克雅未克的社区居住老年人群。
冰岛雷克雅未克的 4753 名社区居住的男性和女性（平均年龄 76±6 岁）。
根据中年检查时报告的每周定期 PA 小时数，将参与者分为活跃或不活跃。晚年 LEF 的测量指标为 6 米步行的步态速度、计时起立行走（TUG）和膝关节伸展（KE）力量测试。线性回归分析用于检验相关性。
与中年不活跃的参与者相比，中年活跃的参与者在晚年的 LEF 表现更好（更快的步态速度，β=0.50，P≤0.001；更快的 TUG 时间，β=-0.53，P≤0.001；更强的 KE 力量，β=1.3，P≤0.001），经过调整社会人口学和心血管危险因素后。在调整晚年认知功能（处理速度、记忆和执行功能）后，中年活跃的参与者在晚年的步态速度（β=0.04，P≤0.001）、TUG 时间（β=-0.34，P≤0.001）和 KE 力量（β=0.87，P≤0.001）方面明显更快，而中年不活跃的参与者则不然。
中年时期有规律的 PA 与晚年更好的 LEF 表现相关，即使在控制晚年认知功能后也是如此。
