Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
J Am Geriatr Soc. 2013 Jan;61(1):79-83. doi: 10.1111/jgs.12069.
To determine the association between change in pulmonary function (PF) and mid- and late-life cognitive function.
Prospective population-based cohort study that included measures of pulmonary function in midlife and brain magnetic resonance imaging data acquired in late life.
The Age, Gene/Environment Susceptibility-Reykjavik Study.
Three thousand six hundred sixty-five subjects who had at least one measure of forced expiratory volume in 1 second (FEV(1)) and were cognitively tested on average 23 years later. A subset of 1,281 subjects had two or three measures of FEV(1) acquired over a 7.8-year period.
Pulmonary function was estimated as FEV(1)/height(2). Rate of PF decline was estimated as the slope of decline over time. Cognitive status was measured with continuous scores of memory, speed of processing, and executive function and as the outcome of mild cognitive impairment (MCI) and dementia.
Lower PF measured in midlife predicted poorer memory, slower speed of processing, poorer executive function, and greater likelihood of MCI and dementia 23 years later. Decrease in PF over a 7.8-year period in midlife was not associated with MCI or dementia.
Low PF measured in midlife may be an early marker of later cognitive problems. Additional studies characterizing early and late PF changes are needed.
确定肺功能（PF）变化与中年和晚年认知功能之间的关联。
一项前瞻性的基于人群的队列研究，包括中年时的肺功能测量和晚年时的脑磁共振成像数据。
雷克雅未克年龄、基因/环境易感性研究。
3665 名受试者，他们至少有一次用力呼气量（FEV1）测量值，并且平均在 23 年后接受认知测试。1281 名受试者中有一部分在 7.8 年内进行了两次或三次 FEV1 测量。
肺功能估计为 FEV1/身高（2）。PF 下降率估计为随时间下降的斜率。认知状态通过记忆、处理速度和执行功能的连续评分以及轻度认知障碍（MCI）和痴呆的结果进行测量。
中年时较低的 PF 测量值预示着较差的记忆、较慢的处理速度、较差的执行功能以及更高的 MCI 和痴呆的可能性。中年期间 PF 下降率在 7.8 年内与 MCI 或痴呆无关。
中年时较低的 PF 测量值可能是日后认知问题的早期标志物。需要进一步研究描述早期和晚期 PF 变化。
