Le Floch J P, Christin S, Bertherat J, Perlemuter L, Hazard J
Département de diabétologie, Centre Hospitalo-Universitaire Henri Mondor, Créteil, France.
Diabete Metab. 1990 Jan-Feb;16(1):26-9.
To specify the influence of blood pressure on diabetic microangiopathy, the factors related to retinopathy and nephropathy were studied among 56 consecutive type 1 (insulin-dependent) diabetic out-patients without hypertension. Diabetes mellitus had been diagnosed for at least one year (mean duration of diabetes +/- SEM = 11.4 +/- 0.9 years). Diabetic patients did not take any treatment liable to influence blood pressure. Clinical parameters, including blood pressure, tobacco and alcohol consumption, were recorded by the same investigator. Retinopathy was defined as more than 5 microaneurysms on a fluorescein angiogram, clinical and incipient nephropathy as an albumin excretion rate over than 300 mg/d and between 30 and 300 mg/d, respectively. On average, retinopathy (n = 25) was associated with longer duration of diabetes (16.5 +/- 1.2 vs 7.4 +/- 0.9 years; p less than 0.001) and higher systolic blood pressure (136.2 +/- 4.1 vs 126.3 +/- 2.8 mm Hg; p less than 0.05). Clinical (n = 9) and incipient (n = 23) nephropathies were associated with duration of diabetes (17.9 +/- 2.0 and 11.8 +/- 1.7 vs 8.7 +/- 1.6 years, respectively; p less than 0.01), and with systolic (145.0 +/- 7.9, 132.7 +/- 4.7 vs 123.5 +/- 4.2 mm Hg; p less than 0.01) and diastolic blood pressure (83.3 +/- 6.2, 77.3 +/- 3.2 vs 72.2 +/- 3.4 mm Hg; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
为明确血压对糖尿病微血管病变的影响，我们对56例无高血压的1型（胰岛素依赖型）糖尿病门诊患者进行了与视网膜病变和肾病相关因素的研究。糖尿病已确诊至少1年（糖尿病平均病程±标准误=11.4±0.9年）。糖尿病患者未接受任何可能影响血压的治疗。包括血压、烟酒摄入情况在内的临床参数由同一名研究者记录。视网膜病变定义为荧光素血管造影显示有超过5个微动脉瘤，临床肾病和早期肾病分别定义为白蛋白排泄率超过300mg/d和在30至300mg/d之间。平均而言，视网膜病变（n=25）与糖尿病病程较长（16.5±1.2对7.4±0.9年；p<0.001）及收缩压较高（136.2±4.1对126.3±2.8mmHg；p<0.05）相关。临床肾病（n=9）和早期肾病（n=23）与糖尿病病程（分别为17.9±2.0和11.8±1.7对8.7±1.6年；p<0.01）以及收缩压（145.0±7.9、132.7±4.7对123.5±4.2mmHg；p<0.01）和舒张压（83.3±6.2、77.3±3.2对72.2±3.4mmHg；p<0.05）相关。（摘要截选至250词）
