文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

St Popova J, Petkov V V

Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

Gen Pharmacol. 1990;21(2):223-5. doi: 10.1016/0306-3623(90)90905-2.

Prolonged (3 month) individual housing of Wistar rats produced aggressive muricidal behavior in 28% of the animals. 2. Binding studies with [3H]5-HT showed that the affinity (Kd) of 5-HT1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. 3. The affinity of 5-HT1 receptors was also significantly decreased in the striatum, hippocampus and hypothalamus of isolated nonaggressive rats. 4. The number (Bmax) of 5-HT1 receptors was significantly decreased in the hippocampus and hypothalamus of isolated aggressive rats and in isolated nonaggressive rats it was decreased only in the hypothalamus. 5. The data suggest that aggressive muricidal behavior in rats with syndrome of social isolation is connected with the decreased activity of brain 5-HT1 receptors.

将Wistar大鼠长期（3个月）单独饲养，28%的动物出现了攻击性杀鼠行为。2. 用[3H]5 - 羟色胺（5 - HT）进行的结合研究表明，与群居大鼠相比，隔离的攻击性大鼠额叶皮质、纹状体、海马体和下丘脑的5 - HT1受体亲和力（Kd）显著降低。3. 隔离的非攻击性大鼠纹状体、海马体和下丘脑的5 - HT1受体亲和力也显著降低。4. 隔离的攻击性大鼠海马体和下丘脑的5 - HT1受体数量（Bmax）显著减少，而隔离的非攻击性大鼠仅下丘脑的受体数量减少。5. 数据表明，社会隔离综合征大鼠的攻击性杀鼠行为与脑5 - HT1受体活性降低有关。

St Popova J, Petkov V V

Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

Gen Pharmacol. 1990;21(2):223-5. doi: 10.1016/0306-3623(90)90905-2.

Prolonged (3 month) individual housing of Wistar rats produced aggressive muricidal behavior in 28% of the animals. 2. Binding studies with [3H]5-HT showed that the affinity (Kd) of 5-HT1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. 3. The affinity of 5-HT1 receptors was also significantly decreased in the striatum, hippocampus and hypothalamus of isolated nonaggressive rats. 4. The number (Bmax) of 5-HT1 receptors was significantly decreased in the hippocampus and hypothalamus of isolated aggressive rats and in isolated nonaggressive rats it was decreased only in the hypothalamus. 5. The data suggest that aggressive muricidal behavior in rats with syndrome of social isolation is connected with the decreased activity of brain 5-HT1 receptors.

将Wistar大鼠长期（3个月）单独饲养，28%的动物出现了攻击性杀鼠行为。2. 用[3H]5 - 羟色胺（5 - HT）进行的结合研究表明，与群居大鼠相比，隔离的攻击性大鼠额叶皮质、纹状体、海马体和下丘脑的5 - HT1受体亲和力（Kd）显著降低。3. 隔离的非攻击性大鼠纹状体、海马体和下丘脑的5 - HT1受体亲和力也显著降低。4. 隔离的攻击性大鼠海马体和下丘脑的5 - HT1受体数量（Bmax）显著减少，而隔离的非攻击性大鼠仅下丘脑的受体数量减少。5. 数据表明，社会隔离综合征大鼠的攻击性杀鼠行为与脑5 - HT1受体活性降低有关。