大鼠着床过程中前列腺素与环磷酸腺苷之间的关系

Relationship between prostaglandins and cyclic-AMP in the process of implantation in rats.

作者信息

Garg S K, DeSouza A N, Chaudhury R R

出版信息

Prostaglandins Med. 1979 Jul;3(1):1-6. doi: 10.1016/0161-4630(79)90010-7.

Abstract

The effect of alloxan, a known inhibitor of adenylate cyclase, on the levels of prostaglandins E and F was investigated in pregnant rats. Animals were treated intraluminally with alloxan in normal saline or alloxan plus cyclic-AMP in normal saline or normal saline alone on day 4 of pregnancy. The uteri were collected on days 5 and 6 of pregnancy and the prostaglandins E and F were extracted and measured by a radioimmunoassay technique. In the alloxan treated rats, a significant reduction in PGE and PGF levels was found on days 5 and 6 of pregnancy as compared to untreated control group, whereas in the alloxan plus cyclic-AMP treated group the levels of PGE and PGF were comparable to those of the untreated control group. These findings suggest a possible relationship between prostaglandins and cyclic-AMP in the process of implantation in rats.

摘要

在怀孕大鼠中，研究了已知的腺苷酸环化酶抑制剂四氧嘧啶对前列腺素E和F水平的影响。在妊娠第4天，对动物进行腔内注射，分别注射生理盐水溶解的四氧嘧啶、生理盐水溶解的四氧嘧啶加环磷酸腺苷或仅注射生理盐水。在妊娠第5天和第6天收集子宫，提取前列腺素E和F，并通过放射免疫测定技术进行测量。与未处理的对照组相比，在接受四氧嘧啶处理的大鼠中，妊娠第5天和第6天的PGE和PGF水平显著降低，而在四氧嘧啶加环磷酸腺苷处理组中，PGE和PGF水平与未处理的对照组相当。这些发现表明，在大鼠着床过程中，前列腺素和环磷酸腺苷之间可能存在某种关系。