类固醇激素对靶组织中PGF/PGE比值的调节作用。

The regulatory role of steroid hormones on the PGF/PGE ratio in target tissues.

作者信息

Kuehl F A, Cirillo V J, Zanetti M E, Beveridge G C, Ham E A

出版信息

Agents Actions. 1976 Feb;6(1-3):165-70. doi: 10.1007/BF01972202.

DOI:10.1007/BF01972202

PMID:181966

Abstract

Estrogen has been found to regulate cyclic nucleotide and prostaglandin levels in the rat uterus. This action of estrogen is associated with a simultaneous rise in cyclic GMP and PFG levels. Alterations in PG levels are either independent of or secondary to the formation of cyclic GMP. The mechanism by which estrogen induces the rise in uterine PGFs, although not precisely defined, is associated with alterations of the enzymes rather than of the substrates involved with prostglandin synthesis.

摘要

已发现雌激素可调节大鼠子宫中的环核苷酸和前列腺素水平。雌激素的这一作用与环鸟苷酸（cGMP）和前列腺素F（PGF）水平的同时升高有关。PG水平的变化要么独立于环鸟苷酸的形成，要么是其形成的继发结果。雌激素诱导子宫PGF升高的机制虽然尚未明确界定，但与参与前列腺素合成的酶的改变有关，而非与底物的改变有关。