金（I）催化丙二酰胺衍生的 1,6-烯炔的分子内氧化环丙烷化反应与二苯砜。
Au(I)-catalyzed intramolecular oxidative cyclopropanation of 1,6-enynes derived from propiolamides with diphenyl sulfoxide.
机构信息
Department of Chemistry, Hanyang University, Seoul, 133-791, Korea.
出版信息
Org Biomol Chem. 2013 Feb 21;11(7):1089-92. doi: 10.1039/c2ob27394b.
PMID:23321793
Abstract
We have developed gold(I)-catalyzed oxidative cyclopropanation of 1,6-enynes derived from propiolamides employing diphenyl sulfoxide as an oxidant. 1,6-Enynes having a terminal alkyne and a propiolamide tether efficiently transformed into cyclopropane carboxaldehyde derivatives.
摘要
我们开发了一种金（I）催化的氧化环丙烷化反应，该反应使用二苯砜作为氧化剂，由丙二酰胺衍生的 1,6-烯炔参与反应。具有末端炔基和丙二酰胺连接基的 1,6-烯炔能够有效地转化为环丙烷羧醛衍生物。
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