Bauernfeind A, Przyklenk B, Matthias C, Jungwirth R, Bertele R M, Harms K
Max-von-Pettenkofer-Institut, Munich, FR Germany.
Infection. 1990 Mar-Apr;18(2):126-30. doi: 10.1007/BF01641436.
Susceptibility in vitro of 179 staphylococcal strains from 107 cystic fibrosis patients against 31 antibiotics indicates that only teicoplanin, vancomycin and netilmicin were active against all strains. The use of betalactam antibiotics is impaired by 11.7% of methicillin-resistant strains. The bactericidal kinetics of cephalexin and flucloxacillin as determined in a pharmacodynamic model demonstrates the killing of strains resistant to cephalexin (MIC 8 mg/l to 32 mg/l) by flucloxacillin. For the rational selection of antistaphylococcal antibiotics for cystic fibrosis patients, both the MIC of the isolates and the concentration of the antibiotics in cystic fibrosis patients have to be considered.
对107例囊性纤维化患者的179株葡萄球菌菌株进行的体外药敏试验表明，仅替考拉宁、万古霉素和奈替米星对所有菌株均有活性。11.7%的耐甲氧西林菌株影响了β-内酰胺类抗生素的使用。在药效学模型中测定的头孢氨苄和氟氯西林的杀菌动力学表明，氟氯西林可杀死对头孢氨苄耐药（MIC为8mg/L至32mg/L）的菌株。为了合理选择用于囊性纤维化患者的抗葡萄球菌抗生素，必须同时考虑分离菌株的MIC以及囊性纤维化患者体内抗生素的浓度。
