Strandvik B, Hollsing A, Möllby R, Granström M
Department of Pediatrics, Huddinge University Hospital, Sweden.
Infection. 1990 May-Jun;18(3):170-2. doi: 10.1007/BF01642107.
Chronic colonization with Staphylococcus aureus is found in 40-50% of the sputum producing patients with cystic fibrosis treated at Stockholm's Cystic Fibrosis Center, Huddinge University Hospital. 30-40% of these patients had increased ELISA IgG antibody titres against teichoic acid and against alpha-toxin. About half of the number of patients showed increased antibody titres to either antigen during infection. Increased antibody titres against staphylococcal antigens were only found in less than or equal to 10% of patients not chronically colonized with S. aureus (no different from the normal population). The serum titres of antistaphylococcal antibodies were significantly higher in the chronically colonized patients (p less than 0.001). Patients who were also chronically harbouring Pseudomonas aeruginosa had the highest titres of both antibodies. The titres increased with clinical signs of infection and were normalized by antimicrobial chemotherapy. To conclude, the use of ELISA IgG antibodies may prove suitable for routine evaluation of the need for, and control of the efficacy of antistaphylococcal chemotherapy in cystic fibrosis.
在胡丁厄大学医院斯德哥尔摩囊性纤维化中心接受治疗的、咳痰的囊性纤维化患者中，40%-50%被发现长期携带金黄色葡萄球菌。这些患者中，30%-40%针对磷壁酸和α-毒素的ELISA IgG抗体滴度升高。约半数患者在感染期间针对其中一种抗原的抗体滴度升高。在未长期携带金黄色葡萄球菌的患者中，仅不到或等于10%的患者发现针对葡萄球菌抗原的抗体滴度升高（与正常人群无差异）。长期携带金黄色葡萄球菌患者的抗葡萄球菌抗体血清滴度显著更高（p<0.001）。同时长期携带铜绿假单胞菌的患者两种抗体的滴度最高。滴度随感染临床症状而升高，并通过抗菌化疗恢复正常。总之，ELISA IgG抗体的应用可能适用于对囊性纤维化患者抗葡萄球菌化疗需求的常规评估及其疗效监测。
