Goering R V, Bauernfeind A, Lenz W, Przyklenk B
Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Infection. 1990 Jan-Feb;18(1):57-60. doi: 10.1007/BF01644187.
An epidemiological analysis of Staphylococcus aureus was conducted in a study group of 157 cystic fibrosis patients cultured over a 30-month period. The resulting S. aureus isolates were categorized by bacteriophage type, plasmid profile, and (in some instances) chromosomal restriction fragment pattern of the culture-positive patients with S. aureus (34 of 157) 44% only were sporadically infected while 68% shared identical strains with one or more other patients. Six patients exhibited persistent infection (for up to ten months) which, in three individuals, occurred as cycles of carriage and reappearance. By contributing toward our understanding of the persistence and spread of S. aureus in cystic fibrosis patients these data should aid in clarifying the role this organism may play in the course of the disease.
对157例囊性纤维化患者进行了一项研究，这些患者在30个月的时间里进行了培养，对金黄色葡萄球菌进行了流行病学分析。从培养阳性的金黄色葡萄球菌患者（157例中的34例）中分离出的金黄色葡萄球菌菌株，根据噬菌体类型、质粒图谱以及（在某些情况下）染色体限制性片段模式进行分类。仅44%的患者为散发性感染，而68%的患者与其他一名或多名患者具有相同菌株。6例患者出现持续感染（长达10个月），其中3例表现为携带和再次出现的循环。通过有助于我们了解金黄色葡萄球菌在囊性纤维化患者中的持续存在和传播，这些数据应有助于阐明该生物体在疾病过程中可能发挥的作用。
