Department of Neurology, Washington University in Saint Louis, St Louis, MO 63110, USA.
Mult Scler. 2013 Aug;19(9):1204-8. doi: 10.1177/1352458512473362. Epub 2013 Jan 15.
CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.
趋化因子 (C-X-C 基元) 配体 13(CXCL13) 已被提议作为多种情况下的生物标志物，其中一些可模拟多发性硬化症，且水平可能非常高。在这项病例对照研究中，与非炎症性对照组相比，多发性硬化症、视神经脊髓炎和其他炎症性神经对照组的脑脊液 (CSF) CXCL13 升高。水平并未区分疾病组。对于所有受试者，CSF CXCL13 与 CSF WBC、寡克隆条带数量、CSF 蛋白、EDSS 和神经丝水平相关。在亚组分析中，CSF CXCL13 与视神经脊髓炎中的 CSF WBC 以及多发性硬化症中的 IgG 指数相关。此外，视神经脊髓炎患者的血清 CXCL13 升高。
