Aganovic Damir, Prcic Alen, Kulovac Benjamin, Hadziosmanovic Osman
Urologiy clinic, Sarajevo University Clinical Center, Bosnia and Herzegovina.
Acta Inform Med. 2012 Mar;20(1):18-21. doi: 10.5455/aim.2012.20.19-21.
To determine the optimal medication for the treatment of renal colic using evidence based medicine (EBM) parameters (RR, ARR, NNT, NNH, ARI, RRI).
During 2010, an ITT study was conducted on 400 outpatients of the Sarajevo University Clinical Center Urology Clinic in order to investigate renal colic pain relief drugs. Each group consisting of 100 patients was administered either Metamizol amp. i.v., or Diclofenac amp. i.m., or Butylscopolamine amp. i.v., while 100 patients belonged to the placebo group that was given distilled water (aqua redestilata). All patients completed visual analogue pain scale (VAPS) from 0 to 10 prior to and after the treatment.
Using EBM parameters Diclofenac Na and Metamizol were shown to be the most efficient in the treatment of renal colic. In these two groups, relative risk (RR) was 21 and 8,5% respectively; Absolute Risk Reduction (ARR) was 74 and 86% respectively, and Number Needed to Treat (NNT) was 1 for both groups, while chi-squared (X2) test has shown that there is no statistically significant difference between these two drugs when it comes to their effect. In the Butylscopolamine group, RR was 81; ARR 18%, while NNT was 5. With respect to side effects, only in his group it was shown that Relative Risk Increase (RRI) was 84, ARI 83%, while Number Needed to Harm (NNH) was 2.
The most optimal medication for the treatment of renal colic according to EBM parameters is Diclofenac Na, followed by Metamizol. Butylscopolamine is not recommended for the treatment of renal colic.
运用循证医学（EBM）参数（相对危险度、绝对危险度降低率、需治疗人数、需伤害人数、归因危险度增加率、相对危险度增加率）确定治疗肾绞痛的最佳药物。
2010年期间，在萨拉热窝大学临床中心泌尿外科门诊对400名门诊患者进行了意向性分析研究，以调查缓解肾绞痛的药物。每组100名患者，分别静脉注射安乃近、肌肉注射双氯芬酸、静脉注射丁溴东莨菪碱，另有100名患者属于安慰剂组，给予蒸馏水。所有患者在治疗前后均完成了0至10的视觉模拟疼痛量表（VAPS）评分。
运用EBM参数显示，双氯芬酸钠和安乃近在治疗肾绞痛方面最为有效。在这两组中，相对危险度（RR）分别为21%和8.5%；绝对危险度降低率（ARR）分别为74%和86%，两组的需治疗人数（NNT）均为1，而卡方（X2）检验表明，这两种药物在疗效方面无统计学显著差异。在丁溴东莨菪碱组中，RR为81%；ARR为18%，而NNT为5。关于副作用，仅在该组显示相对危险度增加率（RRI）为84%，归因危险度增加率（ARI）为83%，而需伤害人数（NNH）为2。
根据EBM参数，治疗肾绞痛的最佳药物是双氯芬酸钠，其次是安乃近。不推荐使用丁溴东莨菪碱治疗肾绞痛。
