Kim Sung Eun, Park Ji Hye, Hong Soonwon, Koo Ja Seung, Jeong Joon, Jung Woo-Hee
Department of Pathology, Gangnam Sevrance Hsopital, Yonsei University College of Medicine, Seoul, Korea.
Korean J Pathol. 2012 Dec;46(6):611-6. doi: 10.4132/KoreanJPathol.2012.46.6.611. Epub 2012 Dec 26.
Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.
乳腺黏液性囊腺癌（MCA）是一种罕见的肿瘤。目前已报道了13例原发性乳腺MCA病例。MCA表现为绝经后女性体内的一个大的、部分为囊性的肿块，预后良好。显微镜下表现类似于卵巢、胰腺或阑尾的MCA。抽吸物检查结果显示，在黏液和坏死物质背景中有含黏液的细胞簇。细胞簇内有胞质黏液，将非典型细胞核挤向周边。组织学上，肿瘤显示有丰富的黏液池，伴有含黏液的肿瘤细胞小漂浮簇。还有一些小囊肿，内衬单层高柱状黏液细胞，类似于子宫颈内膜。癌细胞黏液（MUC）5阳性，MUC2和MUC6阴性。这种黏液谱不同于普通黏液性癌，可能是乳腺MCA的一个独特特征。
