Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea.
Korean Circ J. 2012 Dec;42(12):823-9. doi: 10.4070/kcj.2012.42.12.823. Epub 2012 Dec 31.
This study was intended to test how the inflammation at the Bacille Calmette-Guérin (BCG) inoculation site (BCGitis) can be a useful a diagnostic feature of Kawasaki disease (KD).
All subjects were infants at the time of admission, and had received BCG vaccination during their neonatal period. There were 54 patients with complete KD (group 1) and 29 patients with incomplete KD (group 2). All 83 patients had BCGitis during the acute phase of illness. Data regarding the coronary artery diameters in 31 age-matched controls were used for comparison.
The 2 patient groups did not differ in clinical and laboratory variables. During the acute phase, the median z scores of the left anterior descending coronary artery (LAD) diameter were 0.20, 0.42, and -0.48 in groups 1, 2, and control respectively, and that of right coronary artery (RCA) diameters were -0.15, -0.16, and -1.17 respectively. The z scores in both patient groups were greater than those in controls (p=0.0014 in LAD and p<0.0001 in RCA between group 1 and controls; p=0.0023 in LAD and p<0.0001 in RCA between group 2 and controls). A similar pattern was observed during the subacute and convalescent phases.
BCGitis is a useful feature in the diagnosis of incomplete KD in infants who received BCG vaccine during neonatal period.
本研究旨在检验卡介苗接种部位炎症（卡介苗炎）能否成为川崎病（KD）的有用诊断特征。
所有研究对象在入院时均为婴儿，且在新生儿期接受过卡介苗接种。共有 54 例完全 KD 患儿（组 1）和 29 例不完全 KD 患儿（组 2）。所有 83 例患儿在疾病急性期均出现卡介苗炎。将 31 例年龄匹配的对照组的冠状动脉直径数据用于比较。
两组患儿在临床和实验室变量方面无差异。在急性期，左前降支（LAD）直径的中位数 z 评分分别为组 1、组 2 和对照组的 0.20、0.42 和-0.48，右冠状动脉（RCA）直径的中位数 z 评分分别为-0.15、-0.16 和-1.17。两组患儿的 z 评分均大于对照组（LAD 中组 1 与对照组之间，p=0.0014；RCA 中组 1 与对照组之间，p<0.0001；LAD 中组 2 与对照组之间，p=0.0023；RCA 中组 2 与对照组之间，p<0.0001）。在亚急性期和恢复期也观察到类似的模式。
在新生儿期接受卡介苗接种的婴儿中，卡介苗炎是诊断不完全 KD 的有用特征。
