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利用 microPET 成像在缺血性中风治疗中对针灸效果进行定量验证。

Using microPET imaging in quantitative verification of the acupuncture effect in ischemia stroke treatment.

机构信息

State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

Sci Rep. 2013;3:1070. doi: 10.1038/srep01070. Epub 2013 Jan 15.

DOI:10.1038/srep01070
PMID:23323213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3545224/
Abstract

Acupuncture has been indispensable in Chinese medicine. However, its function still remains elusive. This paper studies the effect of acupuncture in ischemia stroke treatment using the Sprague Dawley rat animal model. We induced focal cerebral ischemia in rats using the middle cerebral artery occlusion (MCAO) procedure. For each rat in the real acupuncture group (n = 63), the sham acupoint treatment group (n = 62), and the blank control group (n = 30), we acquired 3-D fluorodeoxyglucose-microPET images at baseline, after MCAO, and after treatment, respectively. Then, we measured the changes of the injury-volume in the right hemisphere of these rats. The measurements showed that real acupuncture slightly reduced the injury-volume, sham acupoint treatment increased the injury-volume, and blank control had no obvious effect in reducing the injury-volume. Statistical tests also confirmed that acupuncture was more effective than random stimulus in improving the metabolic recovery after stroke.

摘要

针灸在中医中不可或缺。然而，它的功能仍然难以捉摸。本文使用 Sprague Dawley 大鼠动物模型研究针灸在缺血性中风治疗中的作用。我们使用大脑中动脉闭塞 (MCAO) 程序诱导大鼠局灶性脑缺血。对于真实针灸组（n = 63）、假针刺组（n = 62）和空白对照组（n = 30）中的每只大鼠，我们分别在基线、MCAO 后和治疗后获得 3-D 氟脱氧葡萄糖微 PET 图像。然后，我们测量这些大鼠右侧半脑损伤体积的变化。测量结果表明，真实针灸可轻微减少损伤体积，假针刺治疗增加损伤体积，空白对照组在减少损伤体积方面没有明显作用。统计检验也证实，与随机刺激相比，针灸在改善中风后代谢恢复方面更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/6d7c93a6e771/srep01070-f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/e4665a0ce0cb/srep01070-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/6d7c93a6e771/srep01070-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/9eb48c4ca746/srep01070-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/35c6de76c9a7/srep01070-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/a26f46827878/srep01070-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/efaed3fde87c/srep01070-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/45bcb95d96a0/srep01070-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/3706505e7ed8/srep01070-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/fafe2290d0f3/srep01070-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/e4665a0ce0cb/srep01070-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d22/3545224/6d7c93a6e771/srep01070-f9.jpg

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2
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3
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Neurosci Bull. 2022 Sep;38(9):1057-1068. doi: 10.1007/s12264-022-00865-2. Epub 2022 May 31.
4
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Neural Regen Res. 2022 Jul;17(7):1545-1555. doi: 10.4103/1673-5374.330617.
5
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