大脑中动脉闭塞后大鼠中，手动刺激真实穴位与非穴位的特定神经保护作用。
Specific neuroprotective effects of manual stimulation of real acupoints versus non-acupoints in rats after middle cerebral artery occlusion.
作者信息
Li Xin Ling, Fan Nong Xiao, Meng Hong Zhi, Shi Min Xue, Luo Ding, Zhang Nan Ya
机构信息
Postgraduate Department of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; Department of Rehabilitation Medicine, West China Medical School, West China Hospital Sichuan University, 37 Guoxue Xiang, Wuhou District, Chengdu 610041, Sichuan, China.
出版信息
Afr J Tradit Complement Altern Med. 2013 May 16;10(4):186-95. doi: 10.4314/ajtcam.v10i4.30. eCollection 2013.
The objective of this study was to investigate the effectiveness and specific effects of acupuncture on ischemic-induced damage in rats after permanent middle cerebral artery occlusion. Cerebral ischemia was induced by middle cerebral artery occlusion in male Wistar rats. The rats were divided into the following 4 groups: normal controls, ischemic, real acupuncture-treated (Shuigou, DU26), and non-acupoint-treated groups. On the third postoperative day, neurological deficit scores, cerebral blood flow, infarction volume, and neuronal cell death counts were measured. In the real acupuncture-treated group, the neurological deficit scores and cerebral blood flow were improved (p < 0.05) and the infarction volume and neuronal cell death counts were reduced (p < 0.01) compared to the ischemic and non-acupoint-treated groups. The present study demonstrated that real acupuncture was effective against focal ischemia-induced damage in rats after middle cerebral artery occlusion, and the effects were specifically related to the right needling location.
本研究的目的是探讨针刺对永久性大脑中动脉闭塞后大鼠缺血性损伤的有效性及具体作用。采用大脑中动脉闭塞法诱导雄性Wistar大鼠发生脑缺血。将大鼠分为以下4组：正常对照组、缺血组、真穴针刺治疗组（水沟，督脉26）和非穴位治疗组。术后第3天，测量神经功能缺损评分、脑血流量、梗死体积和神经元细胞死亡计数。与缺血组和非穴位治疗组相比，真穴针刺治疗组的神经功能缺损评分和脑血流量得到改善（p < 0.05），梗死体积和神经元细胞死亡计数减少（p < 0.01）。本研究表明，真穴针刺对大脑中动脉闭塞后大鼠局灶性缺血性损伤有效，且其效果与正确的针刺部位密切相关。
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