Natural Product Chemistry, Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500 007, India.
Org Lett. 2013 Feb 1;15(3):464-7. doi: 10.1021/ol303206w. Epub 2013 Jan 16.
A novel method has been devised for the synthesis of 2,4,5-trisubstituted pyrrole derivatives through the coupling of α-diazoketones with β-enaminoketones and esters using 10 mol % of Cu(OTf)(2). A wide range of 2,3-disubstituted indole derivatives were also prepared from α-diazoketones and 2-aminoaryl or alkyl ketones. The synthetic versatility of this approach has been exemplified in the formal synthesis of homofascaplysin C.
一种新方法已经被设计出来，用于通过α-重氮酮与β-烯胺酮和酯的偶联反应，使用 10 mol%的 Cu(OTf)(2)来合成 2,4,5-三取代的吡咯衍生物。还可以通过α-重氮酮和 2-氨基芳基或烷基酮来制备广泛的 2,3-二取代的吲哚衍生物。这种方法的合成多功能性在 homofascaplysin C 的形式合成中得到了例证。
