Laboratoire de Synthèse Organique, UMR 7652 CNRS/ Ecole Polytechnique , 91128 Palaiseau Cedex, France.
Org Lett. 2014 Apr 4;16(7):1992-5. doi: 10.1021/ol500544u. Epub 2014 Mar 19.
The radical addition of various α-xanthyl ketones to Boc-protected azetine gives adducts which, when treated with ammonia or primary amines, furnish 2,4-disubstituted, 2,3,4-trisubstituted, and polycyclic pyrroles having a protected aminomethyl group at position 4. An unusual ring-opening was observed in the case of a cyclobutanone precursor.
各种α-蒽基酮的剧烈加成到 Boc 保护的吖嗪上得到加合物，当用氨或伯胺处理时，得到在 4 位具有保护的氨甲基取代基的 2,4-二取代、2,3,4-三取代和多环吡咯。在环丁酮前体的情况下观察到不寻常的开环。
