Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
J Am Chem Soc. 2013 Aug 14;135(32):11712-5. doi: 10.1021/ja405043g. Epub 2013 Aug 5.
A highly effective synthesis of 2,3-fused pyrroles from cyclic ketones has been achieved. The transformation includes a rhodium-catalyzed reaction of 4-alkenyl-1-sulfonyl-1,2,3-triazoles featuring an unusual 4π electrocyclization. The methodology was further extended to the synthesis of indoles using a one-pot reaction starting from 1-ethynylcyclohexenes.
已经实现了一种从环状酮高效合成 2,3-稠合吡咯的方法。该转化包括铑催化的具有不寻常的 4π 电环化的 4-烯基-1-磺酰基-1,2,3-三唑的反应。该方法进一步扩展到使用 1-乙炔基环己烯的一锅反应合成吲哚。
