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氟轻松醋酸酯植入物(Retisert)迟发性自发性分离。

Late spontaneous dissociation of a fluocinolone acetonide implant (Retisert).

出版信息

Ocul Immunol Inflamm. 2013;21(1):77-8. doi: 10.3109/09273948.2012.736588.

DOI:10.3109/09273948.2012.736588
PMID:23323586
Abstract

PURPOSE

To describe a case of spontaneous dissociation of a fluocinolone acetonide implant (Retisert) 5 years following implantation.

DESIGN

Case report.

METHODS

A patient with chronic uveitis underwent placement of a fluocinolone acetonide implant in the right eye in 2006. The patient's inflammation was well controlled and did not recur, so the device was not replaced.

RESULTS

Five years after implantation, the patient presented with a new complaint of a shadow in his vision. The drug pellet was found to have separated spontaneously from the anchoring strut and was floating in the vitreous. Pars plana vitrectomy was performed with removal of the drug pellet, and the anchoring strut was left in place.

CONCLUSIONS

Spontaneous intraocular dissociation of a fluocinolone acetonide implant (Retisert) can occur years after placement, in the absence of trauma or other risk factors. Surgeons and patients must be aware of this potential complication as the implants age.

摘要

目的

描述一例氟轻松醋酸酯植入物(Retisert)在植入 5 年后自发分离的病例。

设计

病例报告。

方法

一名患有慢性葡萄膜炎的患者于 2006 年在右眼植入氟轻松醋酸酯植入物。患者的炎症得到很好的控制,没有复发,因此没有更换设备。

结果

植入 5 年后,患者出现新的视力阴影主诉。发现药物小丸已自发地从锚固支柱上分离,并漂浮在玻璃体中。进行了经睫状体平坦部玻璃体切除术,取出药物小丸,并将锚固支柱留在原处。

结论

氟轻松醋酸酯植入物(Retisert)在植入数年后可在无创伤或其他危险因素的情况下发生眼内自发性分离。随着植入物的老化,外科医生和患者必须意识到这种潜在的并发症。

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2
Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study.氟轻松丙酮缩合物植入物的分离:多中心葡萄膜炎类固醇治疗(MUST)试验及随访研究。
Am J Ophthalmol. 2016 Apr;164:29-36. doi: 10.1016/j.ajo.2015.12.028. Epub 2015 Dec 31.