Inci Mehmet, Sarli Bahadir, Davarci Mursel, Yalcinkaya Fatih Rustu, Rifaioğlu Murat Mehmet, Davran Ramazan, Arica Secil, Motor Sedat, Demirbaş Onur
Department of Urology, Mustafa Kemal University School of Medicine, Hatay, Turkey.
Scand J Urol. 2013 Oct;47(5):384-9. doi: 10.3109/21681805.2012.762038. Epub 2013 Jan 17.
There are limited data on whether there is an association between nocturia, benign prostatic hyperplasia (BPH) and endothelial dysfunction. The aim of the present study was to evaluate whether there is an association between nocturia and endothelial dysfunction in patients with BPH.
Forty-two men with a diagnosis of BPH and 42 age-matched controls were enrolled. All patients were assessed for frequency and duration of nocturia, and prostate volume, completed the International Prostate Symptom Score (IPSS) questionnaire, and underwent brachial flow-mediated dilatation (FMD) evaluation.
There was a negative correlation between FMD and frequency of nocturia (r = -0.879, p < 0.0001). Moreover, there was a negative correlation between duration of nocturia and FMD (r = -0.890, p < 0.0001). In addition, FMD was significantly decreased in the BPH group compared with the control group (6.0 ± 0.09 to 7.8 ± 0.10%) (p = 0.0001).
In patients with BPH, nocturia is associated with endothelial dysfunction and may be an insidious risk factor for cardiovascular disease.
关于夜尿症、良性前列腺增生（BPH）与内皮功能障碍之间是否存在关联的数据有限。本研究的目的是评估BPH患者中夜尿症与内皮功能障碍之间是否存在关联。
纳入42例诊断为BPH的男性患者和42例年龄匹配的对照者。所有患者均接受夜尿频率和持续时间、前列腺体积评估，完成国际前列腺症状评分（IPSS）问卷，并接受肱动脉血流介导的血管舒张（FMD）评估。
FMD与夜尿频率呈负相关（r = -0.879，p < 0.0001）。此外，夜尿持续时间与FMD呈负相关（r = -0.890，p < 0.0001）。此外，与对照组相比，BPH组的FMD显著降低（6.0±0.09至7.8±0.10%）（p = 0.0001）。
在BPH患者中，夜尿症与内皮功能障碍相关，可能是心血管疾病的一个潜在危险因素。
