Gulf Coast Veterinary Specialists, Houston, TX 77027, USA.
J Vet Intern Med. 2013 Mar-Apr;27(2):217-26. doi: 10.1111/jvim.12033. Epub 2013 Jan 16.
Fish oil omega-3 fatty acids, mainly eicosapentaenoic acid and docosahexaenoic acid, are used in the management of several diseases in companion animal medicine, many of which are inflammatory in nature. This review describes metabolic differences among omega-3 fatty acids and outlines potential adverse effects that may occur with their supplementation in dogs and cats with a special focus on omega-3 fatty acids from fish oil. Important potential adverse effects of omega-3 fatty acid supplementation include altered platelet function, gastrointestinal adverse effects, detrimental effects on wound healing, lipid peroxidation, potential for nutrient excess and toxin exposure, weight gain, altered immune function, effects on glycemic control and insulin sensitivity, and nutrient-drug interactions.
鱼油中的 ω-3 脂肪酸，主要为二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），被用于伴侣动物医学中多种疾病的治疗，其中许多疾病本质上是炎症性的。本综述描述了 ω-3 脂肪酸之间的代谢差异，并概述了在犬和猫中补充 ω-3 脂肪酸可能发生的潜在不良反应，特别关注鱼油中的 ω-3 脂肪酸。ω-3 脂肪酸补充的重要潜在不良反应包括血小板功能改变、胃肠道不良反应、对伤口愈合的不利影响、脂质过氧化、潜在的营养过剩和毒素暴露、体重增加、免疫功能改变、对血糖控制和胰岛素敏感性的影响以及营养物质-药物相互作用。
