a Epidemiology , Florida International University , Miami , USA .
Int J Environ Health Res. 2013 Dec;23(6):461-73. doi: 10.1080/09603123.2012.755155. Epub 2013 Jan 16.
Lead is often present in our environment, but its effect on thyroid function is still unclear. In this study, multiple linear regressions were performed between log-transformed blood lead levels and thyroid function parameters of 4652 adults from the 2007-2008 National Health and Nutrition Examination Survey. The models were adjusted for age, gender, race/ethnicity, smoking, alcohol consumption, body mass index, physical activity, iodine intake, medications, and bone mineral density. Blood lead concentrations (mean: 1.52 ± 1.20 μg/dL [range 0.18-33.12]) were inversely associated with total thyroxine (regression coefficients [β]: -0.22 [95% CI: -0.34, -0.09] in the general population, but were not correlated with thyroid stimulating hormone, total or free triiodothyronine, nor free thyroxine. Blood lead may have no effect on the thyroid function; however, it could be associated with decreased concentrations in thyroid-binding proteins.
铅在我们的环境中很常见，但它对甲状腺功能的影响尚不清楚。在这项研究中，对来自 2007-2008 年全国健康和营养检查调查的 4652 名成年人的血铅水平和甲状腺功能参数进行了多元线性回归分析。模型调整了年龄、性别、种族/民族、吸烟、饮酒、体重指数、体力活动、碘摄入量、药物和骨矿物质密度。血铅浓度（平均值：1.52±1.20μg/dL[范围 0.18-33.12]）与总甲状腺素呈负相关（普通人群的回归系数[β]：-0.22[95%CI：-0.34，-0.09]），但与促甲状腺激素、总或游离三碘甲状腺原氨酸、游离甲状腺素无关。血铅可能对甲状腺功能没有影响，但可能与甲状腺结合蛋白浓度降低有关。
