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Am J Ind Med. 2016 Jul;59(7):583-90. doi: 10.1002/ajim.22591. Epub 2016 Apr 20.
2
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.甲状腺激素在骨骼发育和骨骼维持中的作用。
Endocr Rev. 2016 Apr;37(2):135-87. doi: 10.1210/er.2015-1106. Epub 2016 Feb 10.
3
The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men.健康甲状腺功能正常男性的血清促甲状腺激素（TSH）水平与骨密度之间的关系。
Clin Endocrinol (Oxf). 2010 Sep;73(3):396-403. doi: 10.1111/j.1365-2265.2010.03818.x. Epub 2010 Apr 23.
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Multiple metals predict prolactin and thyrotropin (TSH) levels in men.多种金属可预测男性的催乳素和促甲状腺激素（TSH）水平。
Environ Res. 2009 Oct;109(7):869-73. doi: 10.1016/j.envres.2009.06.004.
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High bone matrix turnover predicts blood levels of lead among perimenopausal women.高骨基质周转率可预测围绝经期女性的血铅水平。
Environ Res. 2009 Oct;109(7):880-6. doi: 10.1016/j.envres.2009.06.005.
6
Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada).有机氯、汞和铅对加拿大魁北克湖滨社区甲状腺激素水平影响的性别差异。
Environ Res. 2008 Jul;107(3):380-92. doi: 10.1016/j.envres.2008.01.006. Epub 2008 Mar 4.
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Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements.美国人群的尿肌酐浓度：对尿生物监测测量的影响。
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第三次国家健康与营养调查中血铅水平与血清促甲状腺激素和总甲状腺素的关系。

The relationships between blood lead levels and serum thyroid stimulating hormone and total thyroxine in the third National Health and Nutrition Examination Survey.

机构信息

National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 1150 Tusculum Avenue, Cincinnati, OH 45226, USA.

出版信息

J Trace Elem Med Biol. 2019 Jan;51:130-137. doi: 10.1016/j.jtemb.2018.10.010. Epub 2018 Oct 10.

DOI:10.1016/j.jtemb.2018.10.010
PMID:30466922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8087148/
Abstract

Regression analysis was used to estimate and test for relationships between the blood lead concentration and the concentrations of serum thyroid stimulating hormone and serum total thyroxine in adults, 20 years and older, participating in the third National Health and Nutrition Examination Survey. No relationship was found between the blood lead level and the concentration of serum thyroid stimulating hormone. The serum total thyroxine concentration decreased as the blood lead level increased in women, but not in men. The lowest concentration of blood lead at which a relationship could be detected was 2.1 μg/dL and 3.9 μg/dL for the non-pregnant and pregnant women, respectively. Hypothetical mechanisms of the action of lead are discussed.

摘要

回归分析用于估计和检验成年人（20 岁及以上）血液铅浓度与血清促甲状腺激素和血清总甲状腺素浓度之间的关系，这些成年人参与了第三次国家健康和营养检查调查。未发现血液铅水平与血清促甲状腺激素浓度之间存在关系。在女性中，随着血液铅水平的升高，血清总甲状腺素浓度降低，但在男性中则不然。可以检测到关系的最低血液铅浓度分别为 2.1μg/dL 和 3.9μg/dL，适用于非孕妇和孕妇。讨论了铅作用的假设机制。