微量元素异常与甲状腺功能障碍的关系。
Association of trace elements abnormalities with thyroid dysfunction.
机构信息
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), PO Box 80203, Jeddah, Saudi Arabia.
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
出版信息
Afr Health Sci. 2021 Sep;21(3):1451-1459. doi: 10.4314/ahs.v21i3.56.
BACKGROUND
The metabolic pathways can be affected by dysregulation in thyroid hormone levels which in turn can arise from environmental chemical exposure. This study investigated the association of selected trace elements with thyroid disorders in a Saudi population.
METHODS
Urine samples collected from 100 participants (50 thyroid disorder patients and 50 controls) were analyzed to determine trace elements using inductively coupled plasma-mass spectrometer. Non-parametric Mann-Whitney Test, were used to examine the association between socio-demographic as well as clinical characteristics of thyroid profile levels (T3, T4 and TSH) and urinary trace element concentrations.
RESULTS
Urine from patients with thyroid disorders had significantly higher concentrations of Ni, Cu, and Cd (p-values <0.0005). In contrast, urinary Cr and Zn (p-values <0.013 and 0.005) were low in thyroid patients compared to the control.
CONCLUSION
First study to report urinary trace element levels showed a possible link between thyroid disorders and trace element exposure which reflect the environmental pollution..
背景
甲状腺激素水平的失调会影响代谢途径，而甲状腺激素水平的失调又可能是由于环境化学物质暴露引起的。本研究调查了沙特人群中某些微量元素与甲状腺疾病的关系。
方法
采集了 100 名参与者（50 名甲状腺疾病患者和 50 名对照者）的尿液样本，使用电感耦合等离子体质谱仪分析了微量元素。采用非参数 Mann-Whitney 检验，检验了甲状腺功能指标（T3、T4 和 TSH）和尿微量元素浓度与社会人口统计学及临床特征之间的关系。
结果
甲状腺疾病患者的尿液中 Ni、Cu 和 Cd 的浓度明显较高（p 值<0.0005）。相比之下，甲状腺疾病患者的尿 Cr 和 Zn 浓度较低（p 值<0.013 和 0.005）。
结论
这项研究首次报告了尿液微量元素水平，表明甲状腺疾病与微量元素暴露之间可能存在联系，这反映了环境污染。
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