使用动力学拆分催化剂确定内酰胺和恶唑烷酮的绝对构型。
Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts.
机构信息
Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, California 92697, USA.
出版信息
Org Lett. 2013 Feb 1;15(3):472-5. doi: 10.1021/ol303239t. Epub 2013 Jan 16.
PMID:23323958
Abstract
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.
摘要
本文介绍了一种使用动力学拆分催化剂确定恶唑烷酮、内酰胺及其衍生物绝对构型的简单方法。使用（S）-HBTM 和（R）-HBTM 催化剂对光学纯底物进行酰化，确定较快的反应。基于快速反应的催化剂，开发了一个经验性的助记符来分配绝对构型。
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