Western Australian Institute for Medical Research, B Block, Ground Floor, Hospital Avenue, Nedlands, Western Australia 6009, Australia.
Am J Epidemiol. 2013 Feb 15;177(4):316-27. doi: 10.1093/aje/kws422. Epub 2013 Jan 16.
Breast cancer is one of the most commonly diagnosed invasive cancers. Established risk factors account for only a small proportion of cases. Previous studies have found reductions in sleep duration and quality in the general population over time. There is evidence to suggest a link between poor sleep and an increased risk of breast cancer. In this study, we investigated the relationship between breast cancer and sleep duration and quality in Western Australian women. Data were obtained from a population-based case-control study conducted from 2009 to 2011. Participants completed a self-administered questionnaire that included questions on sleep. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. Sensitivity analysis for potential selection and misclassification bias was also conducted. We found no association between self-reported sleep duration on workdays and risk of breast cancer (for <6 hours, odds ratio (OR) = 1.05 (95% CI: 0.82, 1.33); for 6-7 hours, OR = 0.96 (95% CI: 0.80, 1.16); and for >8 hours, OR = 1.10 (95% CI: 0.87, 1.39), compared with the reference category of 7-8 hours' sleep). In addition, we found no association between sleep duration on nonworkdays, subjective sleep quality, or combined duration and quality and risk of breast cancer. This study does not provide evidence to support an association between self-reported sleep duration or quality and the risk of breast cancer.
乳腺癌是最常见的侵袭性癌症之一。已确定的风险因素仅占少数病例。先前的研究发现，随着时间的推移，普通人群的睡眠时间和睡眠质量有所下降。有证据表明，睡眠质量差与乳腺癌风险增加之间存在关联。在这项研究中，我们调查了西澳大利亚女性的乳腺癌与睡眠时间和睡眠质量之间的关系。数据来自于 2009 年至 2011 年进行的一项基于人群的病例对照研究。参与者完成了一份自我管理的问卷，其中包括有关睡眠的问题。使用无条件逻辑回归计算了比值比和 95%置信区间。还进行了敏感性分析，以评估潜在的选择和分类偏倚。我们没有发现工作日自我报告的睡眠时间与乳腺癌风险之间存在关联（<6 小时，比值比（OR）=1.05（95%CI：0.82, 1.33）；6-7 小时，OR=0.96（95%CI：0.80, 1.16）；>8 小时，OR=1.10（95%CI：0.87, 1.39），与 7-8 小时睡眠的参考类别相比）。此外，我们没有发现非工作日睡眠时间、主观睡眠质量或两者结合的时间和质量与乳腺癌风险之间存在关联。这项研究没有提供证据支持自我报告的睡眠时间或质量与乳腺癌风险之间存在关联。
