Zhang Bao, Tang Mengsha, Li Xiude
Department of Clinical Nutrition, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
School of Humanity and Management, Wannan Medical College, Wuhu, 241002, Anhui, China.
Cancer Causes Control. 2025 May;36(5):457-472. doi: 10.1007/s10552-024-01951-8. Epub 2024 Dec 28.
Breast cancer is the leading cause of cancer-related death and the most common cancer among women worldwide. It is crucial to identify potentially modifiable risk factors to intervene and prevent breast cancer effectively. Sleep factors have emerged as a potentially novel risk factor for female breast cancer. Current epidemiologic studies suggest a significant impact of sleep factors on breast cancer. Exposure to abnormal sleep duration, poor sleep quality, sleep disorders, sleep medication use, or night shift work can increase the risk of breast cancer by decreasing melatonin secretion, disrupting circadian rhythm, compromising immune function, or altering hormone levels. However, there are still controversies regarding the epidemiologic association, and the underlying mechanisms have yet to be fully elucidated. This paper summarizes the epidemiologic evidence on the associations between sleep factors, including sleep duration, sleep quality, sleep disorders, sleep medication use, sleep habits, and night shift work, and the development of breast cancer. The potential mechanisms underlying these associations were also reviewed.
乳腺癌是全球女性中与癌症相关死亡的主要原因，也是最常见的癌症。识别潜在的可改变风险因素对于有效干预和预防乳腺癌至关重要。睡眠因素已成为女性乳腺癌潜在的新风险因素。目前的流行病学研究表明睡眠因素对乳腺癌有重大影响。暴露于睡眠时间异常、睡眠质量差、睡眠障碍、使用助眠药物或从事夜班工作会通过减少褪黑素分泌、扰乱昼夜节律、损害免疫功能或改变激素水平而增加患乳腺癌的风险。然而，关于这种流行病学关联仍存在争议，其潜在机制尚未完全阐明。本文总结了关于睡眠因素（包括睡眠时间、睡眠质量、睡眠障碍、使用助眠药物、睡眠习惯和夜班工作）与乳腺癌发生之间关联的流行病学证据。还对这些关联的潜在机制进行了综述。
