Baranowska Irena, Wojciechowska Iwona, Solarz Natalia, Krutysza Ewa
Department of Analytical Chemistry, Chemical Faculty, Silesian University of Technology, 7 M. Strzody Str, 44-100 Gliwice, Poland.
J Chromatogr Sci. 2014 Jan;52(1):88-94. doi: 10.1093/chromsci/bms210. Epub 2013 Jan 16.
This paper reports the development of a method for simultaneously determining five preservatives in cosmetics, cleaning agents and pharmaceuticals by fast liquid chromatography. Methylisothiazolinone, methylchloroisothiazolinone, benzyl alcohol, sodium benzoate and methylparaben were separated on a Chromolith Fast Gradient reversed-phase 18e column using gradient elution with acetonitrile and a 0.1% aqueous solution of formic acid, with a run time of 3 min. The preparation of solid and liquid samples included ultrasonic extraction with methanol with recoveries ranging from 69 to 119%. The developed method was used to analyze samples of cosmetics (66 samples), cleaning agents (five samples) and pharmaceutical industry products (17 samples).
本文报道了一种通过快速液相色谱法同时测定化妆品、清洁剂和药品中五种防腐剂的方法。使用Chromolith Fast Gradient反相18e柱，以乙腈和0.1%甲酸水溶液进行梯度洗脱，在3分钟内分离甲基异噻唑啉酮、甲基氯异噻唑啉酮、苯甲醇、苯甲酸钠和对羟基苯甲酸甲酯。固体和液体样品的制备包括用甲醇超声提取，回收率在69%至119%之间。所建立的方法用于分析化妆品样品（66个）、清洁剂样品（5个）和制药行业产品样品（17个）。
