Departments of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
JAMA Surg. 2013 Jan;148(1):23-8. doi: 10.1001/jamasurg.2013.677.
To describe the outcomes and the expected postoperative course for patients with do-not-resuscitate (DNR) orders (DNR patients) who undergo emergency surgical management of bowel obstruction.
We retrospectively identified all patients who underwent emergency surgical management of intestinal obstruction and who were classified previously as DNR using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Participant Use Data File for 2005 through 2009. We constructed a forward stepwise multivariate logistic regression model to determine predictors of postoperative mortality. We used propensity score analysis to determine the effect of DNR status on postoperative outcomes.
Institutions participating in the NSQIP.
All patients entered in the NSQIP database.
Thirty-day postoperative mortality and complication rates.
We identified 242 patients who met the study criteria. Mean age was 80.9 years. Thirty-day mortality was 29.8%, with 47.1% of patients experiencing a postoperative complication. The presence of a postoperative complication was an independent predictor of postoperative mortality. Comparison of matched cohorts revealed a significantly higher postoperative mortality in DNR patients even after adjusting for comorbidities and overall complication rate.
Outcomes are poor after emergency surgical intervention for bowel obstruction in elderly DNR patients, with high postoperative complication and mortality rates. The presence of a DNR order is an independent risk factor for postoperative mortality. Patients, their families, and their physicians must be counseled on surgical expectations preoperatively and made aware of the significantly higher risks involved when a DNR order exists in the setting of emergency surgical management of bowel obstruction.
描述有“不复苏”(DNR)医嘱(DNR 患者)的患者接受肠梗阻紧急手术治疗的结果和预期术后过程。
我们回顾性地确定了所有接受肠梗阻紧急手术治疗并使用美国外科医师学会国家手术质量改进计划(NSQIP)参与者使用数据文件在 2005 年至 2009 年期间被归类为 DNR 的患者。我们构建了一个向前逐步多元逻辑回归模型,以确定术后死亡率的预测因素。我们使用倾向评分分析来确定 DNR 状态对术后结果的影响。
参与 NSQIP 的机构。
所有进入 NSQIP 数据库的患者。
术后 30 天死亡率和并发症发生率。
我们确定了符合研究标准的 242 名患者。平均年龄为 80.9 岁。30 天死亡率为 29.8%,47.1%的患者发生术后并发症。术后并发症的存在是术后死亡的独立预测因素。匹配队列的比较显示,即使在调整了合并症和总体并发症发生率后,DNR 患者的术后死亡率仍然明显更高。
在老年 DNR 患者中,肠梗阻紧急手术干预后的结果较差,术后并发症和死亡率较高。DNR 医嘱的存在是术后死亡率的独立危险因素。在肠梗阻紧急手术管理中存在 DNR 医嘱时,必须在术前对患者、其家属和医生进行手术预期的咨询,并让他们意识到涉及的风险显著增加。