Aziz Hassan, Branco Bernardino C, Braun Jonathan, Hughes John D, Goshima Kay R, Trinidad-Hernandez Magdiel, Hunter Glenn, Mills Joseph L
Department of Surgery, University of Arizona, Tucson, Ariz.
Department of Surgery, University of Arizona, Tucson, Ariz.
J Vasc Surg. 2015 Jun;61(6):1538-42. doi: 10.1016/j.jvs.2014.11.087. Epub 2015 Feb 19.
Do-not-resuscitate (DNR) orders allow patients to communicate their wishes regarding cardiopulmonary resuscitation. Although DNR status may influence physician decision making regarding resuscitation, the effect of DNR status on outcomes of patients undergoing emergency vascular operation remains unknown. The aim of this study was to analyze the effect of DNR status on the outcomes of emergency vascular surgery.
The National Surgical Quality Improvement Program database was queried to identify all patients requiring emergency vascular surgical interventions between 2005 and 2010. Demographics, clinical data, and outcomes were extracted. Patients were compared according to DNR status. The primary outcome measure was 30-day mortality.
During the study period, 16,678 patients underwent emergency vascular operations (10.8% of the total vascular surgery population). Of those, 548 patients (3.3%) had a DNR status. The differences in rates of open or endovascular repair or of intraoperative blood requirement between the two groups were not significant. After adjusting for differences in demographics and clinical data, DNR patients were more likely to have higher rates of graft failure (8.7% vs 2.4%; adjusted P < .01) and failure to wean from mechanical ventilation (14.9 % vs 9.9%; adjusted P < .001). DNR status was associated with a 2.5-fold rise in 30-day mortality (35.0% vs 14.0%; 95% confidence interval, 1.7-2.9; adjusted P < .001).
The presence of a DNR order was independently associated with mortality. Patient and family counseling on surgical expectations before emergency vascular operations is warranted because the risks of perioperative events are significantly elevated when a DNR order exists.
“不要复苏”(DNR)医嘱允许患者表达其关于心肺复苏的意愿。尽管DNR状态可能会影响医生关于复苏的决策,但DNR状态对接受急诊血管手术患者预后的影响仍不清楚。本研究的目的是分析DNR状态对急诊血管手术预后的影响。
查询国家外科质量改进计划数据库,以识别2005年至2010年间所有需要进行急诊血管手术干预的患者。提取人口统计学、临床数据和预后信息。根据DNR状态对患者进行比较。主要结局指标是30天死亡率。
在研究期间,16678例患者接受了急诊血管手术(占血管手术总人数的10.8%)。其中,548例患者(3.3%)有DNR状态。两组之间开放或血管腔内修复率或术中血液需求量的差异不显著。在调整了人口统计学和临床数据的差异后,DNR患者更有可能出现较高的移植物失败率(8.7%对2.4%;校正P<0.01)和脱机失败率(14.9%对9.9%;校正P<0.001)。DNR状态与30天死亡率升高2.5倍相关(35.0%对14.0%;95%置信区间,1.7-2.9;校正P<0.001)。
存在DNR医嘱与死亡率独立相关。在急诊血管手术前对患者及其家属进行手术预期方面的咨询是必要的,因为当存在DNR医嘱时,围手术期事件的风险会显著升高。