辐射对正常大鼠脑和9L胶质肉瘤脑肿瘤模型中主要组织相容性复合体表达及淋巴细胞浸润的影响。
The effects of irradiation on major histocompatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model.
作者信息
Wen P, Loeffler J S, Morris J H, Lampson L A
机构信息
Brigham and Women's Hospital, Boston, MA 02115.
出版信息
J Neuroimmunol. 1990 May;27(2-3):239-44. doi: 10.1016/0165-5728(90)90074-w.
Abstract
The effects of irradiation on major histocompatibility complex (MHC) expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model were examined. Doses of irradiation administered were biologically equivalent to that used in the treatment of patients with malignant gliomas. No significant change in immune parameters was observed following irradiation in the normal rat brain. In the 9L gliosarcoma model irradiation did not suppress MHC expression or lymphocytic infiltration. These findings suggest that prior exposure to therapeutic irradiation need not adversely affect subsequent immunotherapies, and provide a foundation for future studies of immunomodulation in the irradiated brain.
摘要
研究了辐射对正常大鼠脑和9L胶质肉瘤脑肿瘤模型中主要组织相容性复合体（MHC）表达及淋巴细胞浸润的影响。所给予的辐射剂量在生物学上等同于治疗恶性胶质瘤患者所使用的剂量。正常大鼠脑在辐射后未观察到免疫参数有显著变化。在9L胶质肉瘤模型中，辐射并未抑制MHC表达或淋巴细胞浸润。这些发现表明，预先接受治疗性辐射不一定会对后续的免疫治疗产生不利影响，并为未来关于辐射脑内免疫调节的研究奠定了基础。
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