Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR6302, Dijon, France.
Chem Commun (Camb). 2013 Feb 21;49(15):1500-2. doi: 10.1039/c2cc38317a.
The capability of DNA to acquire enzyme-like properties has led to the emergence of the so-called DNAzyme field; herein, we take a further leap along this nature-inspired road, demonstrating that a template assembled synthetic G-quartet (TASQ) can act as a pre-catalyst for catalytic peroxidase-mimicking oxidation reactions, whatever its nature (guanine or guanosine-based G-quartets), in an ATP-dependent manner, thereby bringing this bioinspired TASQzyme process even closer to nature.
DNA 获得酶样特性的能力催生了所谓的 DNA 酶领域；在此，我们沿着这条受自然启发的道路更进一步，证明了组装的模板合成 G-四联体（TASQ）可以作为催化过氧化物酶模拟氧化反应的预催化剂，无论其本质如何（基于鸟嘌呤或鸟苷的 G-四联体），以依赖于 ATP 的方式，从而使这种受生物启发的 TASQzyme 过程更接近自然。
