介孔硅纳米颗粒通过级联敏化剂激活和单线态氧敏感连接物的断裂促进药物释放。
Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker.
机构信息
Department of Chemistry, Center for Self-assembly and Complexity, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang, 790-784, Republic of Korea.
出版信息
Chem Commun (Camb). 2013 Feb 21;49(15):1545-7. doi: 10.1039/c2cc38510d.
PMID:23325385
Abstract
A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with long-wavelength light.
摘要
基于介孔硅纳米粒子 (MSN) 开发了一种光响应药物释放系统。通过单线态氧敏感连接物修饰模型药物，并将单线态氧产生的光敏剂装载到 MSN 的介孔中。通过长波长光照射成功开发了一种按需药物释放系统。
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