Singh S K, Rai S B
Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi-221 005, India.
Indian J Pharm Sci. 2012 Mar;74(2):178-83. doi: 10.4103/0250-474X.103858.
Traditional medicines have maintained their popularity in all regions of the developing world and are being adopted increasingly by people worldwide. Indian traditional system of medicine Ayurveda make use of unique metallic-herbal preparations (called Bhasma) which involves different processing steps including repeated steps of calcination of metal in the presence of natural precursor (herbal juices, decoctions, and powders, etc). It has been recently established that Bhasma contains nano/sub-micron size particles and different nutrient elements. However, the role and the end product of the raw materials, especially the herbal parts, used during the synthesis of the drug (Bhasma) is one of the important but unanswered problems in such medicinal preparations. Present work on Naga Bhasma is an attempt to understand the role of natural precursors in detail. Our results on infrared, Raman and X-ray photoelectron spectroscopy along with thermal measurements identify the presence of carbonaceous material (hydrogenated amorphous carbon) in the drug along with other compounds. In addition, this work also suggests the science and mechanism behind such complex preparations which could help in standardization of such medicines.
传统药物在发展中世界的所有地区都一直很受欢迎,并且正越来越多地被世界各地的人们所采用。印度传统医学阿育吠陀利用独特的金属 - 草药制剂(称为“Bhasma”),这涉及不同的加工步骤,包括在天然前体(草药汁、煎剂和粉末等)存在的情况下对金属进行反复煅烧步骤。最近已经确定,Bhasma含有纳米/亚微米尺寸的颗粒和不同的营养元素。然而,在药物(Bhasma)合成过程中使用的原材料,特别是草药部分的作用和最终产物,是此类药物制剂中一个重要但尚未解决的问题。目前关于那伽Bhasma的研究旨在详细了解天然前体的作用。我们在红外、拉曼和X射线光电子能谱以及热测量方面的结果确定了药物中除其他化合物外还存在含碳物质(氢化非晶碳)。此外,这项工作还揭示了此类复杂制剂背后的科学原理和机制,这有助于此类药物的标准化。