Butler J, Leonard B E
Department of Pharmacology, University College, Galway, Ireland.
Int Clin Psychopharmacol. 1990 Jan;5(1):41-8. doi: 10.1097/00004850-199001000-00004.
A decreased rate of uptake of serotonin (5HT) into platelets is recognized as a possible marker of the depressed state, being normalized only by effective antidepressant treatment. Fluoxetine is a novel antidepressant, with 5HT uptake inhibitory properties. In this study, treatment of depressed patients with fluoxetine for up to 6 months did not normalize the decreased platelet 5HT uptake rates associated with depression, although the patients showed a clinical recovery. The olfactory bulbectomized (OB) rat shows a characteristic hyperactivity in a stressful environment, which can be reversed only by chronic treatment with most antidepressants. OB rats have been found to exhibit a decreased rate of platelet 5HT uptake, similar to depressed patients, which is normalized by chronic antidepressant treatment. However, 3 weeks treatment with fluoxetine failed to reverse the hyperactivity of the OB rat and the decreased rates of uptake of 5HT. We also examined the rate of uptake of serotonin into the synaptosomes of the OB rats, in order to elucidate whether platelet 5HT uptake reflected central activity. Chronic fluoxetine treatment failed to normalize high affinity synaptosomal 5HT uptake in the OB rat. Fluoxetine, therefore, unlike most other antidepressants, does not normalize the decreased rates of platelet 5HT uptake in depressed patients on clinical recovery. OB rats also showed a deficit in their platelet and synaptosomal 5HT uptake rates, following 3 weeks treatment with fluoxetine.
血清素（5HT）摄入血小板的速率降低被认为是抑郁状态的一个可能标志，只有通过有效的抗抑郁治疗才能使其恢复正常。氟西汀是一种新型抗抑郁药，具有抑制5HT摄入的特性。在本研究中，用氟西汀治疗抑郁症患者长达6个月，尽管患者临床症状有所恢复，但与抑郁症相关的血小板5HT摄入速率降低并未恢复正常。嗅球切除（OB）大鼠在应激环境中表现出特征性的多动，只有通过大多数抗抑郁药的长期治疗才能逆转。已发现OB大鼠的血小板5HT摄入速率降低，与抑郁症患者相似，通过长期抗抑郁治疗可使其恢复正常。然而，用氟西汀治疗3周未能逆转OB大鼠的多动以及5HT摄入速率降低。我们还检测了OB大鼠突触体中血清素的摄入速率，以阐明血小板5HT摄入是否反映中枢活性。长期用氟西汀治疗未能使OB大鼠高亲和力突触体5HT摄入恢复正常。因此，与大多数其他抗抑郁药不同，氟西汀在抑郁症患者临床症状恢复后并不能使降低的血小板5HT摄入速率恢复正常。在用氟西汀治疗3周后，OB大鼠的血小板和突触体5HT摄入速率也出现了降低。
